In the early 1960s, he began to be a free-lancer for fashion magazines such as Vogue, Harper's Bazaar, Elle, and Andy Warhol's Interview. In 1964, he introduced himself to a couturier Charles James in a New York restaurant and that meeting generate in a collaboration between the young artist and the master that would last more than ten years and produce an illustration of all the clothes that had designed by James. He taught Lopez to appreciate the sculptural quality of clothes, a perspective that had a lasting effect on his drawings.
Lopez worked in close collaboration with Juan Eugene Ramos. And in 1969 he moved to Paris with Ramos and worked with Karl Lagerfeld. He also the one who discovered Jessica Lange in 1974, also discovered Grace Jones and Tina Chow, and discovered Jerry Hall and lived with her in Paris at her beginning in her modelling career. They also helped to introduce American Pop Art to Paris. Lopez's career took him to Paris, Tokyo, Kyoto, Milan, Sidney, Melbourne, and other international locations. He used variety of materials such as pencil, pen and ink, charcoal, water-colour, and Polaroid film, and also pursued jewellery design, conceptual designs; as window displays for Fiorucci and Studio 54, graphic collaboration on interview.
After all his amazing work and great collaborations with so many great designers. He was died of complications related to AIDS in March 17, 1987 at the age 44. His campaigns for Missoni endure as one of the great artist/designer collaborations. But when he was doing his campaign with Missoni which launched at the same time as the 1984 Olympics, he was already ill. The Missoni images are a reminder of how men were as important as women in Lopez's visual vocabulary. That was a rare thing in the annals of fashion.
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